Santa Cruz Vacations & Trips from $371

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Your Santa Cruz Vacation

With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.

Top destinations in Santa Cruz

San Lorenzo Cathedral showing a garden
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Santa Cruz

Santa Cruz
Samaipata is one of Bolivia's hidden gems. Staying in this quiet town gives you access to the beautiful natural areas that surround it. Quick Tip: Taking a stroll down the streets outside the town offer some pretty jungle views and a glimpse of local life in the countryside. #Bolivia #Travel
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Samaipata

Samaipata

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
cabañas la monita

cabañas la monita

3 out of 5
Price was $387, price is now $371 per person
$371
per person
Oct 20 - Oct 23
found 1 day ago
Roundtrip flight included
São Paulo (GRU) to Chimore (CCA)
2/10 (1 review)

Best Places to Vacation in Santa Cruz

1. Plan your dream getaway to Santa Cruz

Santa Cruz, located in Bolivia, offers a unique and vibrant atmosphere for city vacationers. With its diverse range of attractions, including shopping centers, charming cafes, colorful flower markets, a zoo, and various excursions, visitors can immerse themselves in the local culture. The city also boasts a beautiful cathedral and is a haven for birdwatching enthusiasts. For those interested in sports, Santa Cruz is known for its passion for soccer. Additionally, the city has a thriving business scene and offers a wide selection of local beers to enjoy. Overall, Santa Cruz provides a delightful and exciting experience for travelers.

  • The peak season is from July to September
  • The off-peak season is from October to December
  • Travelers tend to stay 4 days in Santa Cruz

2. Escape to Samaipata with a vacation package

Samaipata, located in Santa Cruz, Bolivia, offers a unique outdoor vacation experience. With its diverse geography, this destination is perfect for activities such as hiking, mountain exploration, forest and jungle adventures, camping, and waterfall visits. Wildlife enthusiasts will also enjoy the opportunity for birdwatching and spotting local fauna. Samaipata is also home to an impressive UNESCO World Heritage Site and a zoo. Popular traveler activities include destination activities, tours, and sightseeing. Immerse yourself in the natural beauty and vibrant atmosphere of Samaipata for an unforgettable outdoor vacation.

  • The peak season is from December to February
  • The off-peak season is from October to December
  • Travelers tend to stay 2 days in Samaipata

3. Experience Warnes with a travel package

Warnes, Santa Cruz, Bolivia offers a unique and memorable family vacation experience. The local atmosphere is warm and welcoming, with friendly locals eager to share their culture and traditions. The town is surrounded by beautiful natural landscapes, including lush forests and picturesque mountains, perfect for outdoor activities such as hiking and exploring. Families can also visit local attractions like the Warnes Zoo, which houses a variety of exotic animals, or enjoy traditional Bolivian cuisine at the town's charming restaurants. With its rich history and natural beauty, Warnes is an ideal destination for a family vacation.

  • The peak season is from September to November
  • The off-peak season is from March to May

4. Create memories in San Jose de Chiquitos with a vacation package

San Jose de Chiquitos in Santa Cruz, Bolivia, offers a unique cultural vacation experience. With its sunny weather, lush forests, and stunning natural parks, the town is a haven for nature lovers. Explore the historical urban center and marvel at the beautiful cathedral, a true architectural gem. Immerse yourself in the local culture by visiting the various churches and experiencing their rich traditions. The scenery in San Jose de Chiquitos is breathtaking, with picturesque landscapes and vibrant colors. Whether you're seeking a peaceful retreat or an adventure-filled getaway, this charming town has it all.

  • The peak season is from July to September
  • The off-peak season is from October to December
  • Travelers tend to stay 2 days in San Jose de Chiquitos

6. Explore Roboré with a vacation package

Concepcion, Santa Cruz, Bolivia, offers a rich cultural experience for travelers. The town is known for its churches, waterfalls, cathedral, and natural beauty. Visitors can explore the picturesque lake, enjoy live music performances, and immerse themselves in local festivals. Concepcion also boasts a vibrant theater scene and opportunities to appreciate art in museums. Whether you're seeking a peaceful retreat in nature or a lively cultural experience, Concepcion has something to offer. With its unique blend of tradition and modernity, this Bolivian town promises an unforgettable vacation for culture enthusiasts.

  • The peak season is from December to February
  • The off-peak season is from September to November

5. Discover Concepcion with our vacation deals

Roboré, located in Santa Cruz, Bolivia, offers a unique cultural vacation experience. Immerse yourself in the vibrant local atmosphere as you explore the town's rich heritage and traditions. Discover the region's indigenous culture through captivating art, music, and dance performances. Indulge in the local cuisine, savoring traditional Bolivian dishes bursting with flavors. Engage with friendly locals and learn about their customs and way of life. Explore the breathtaking natural landscapes surrounding Roboré, from lush rainforests to majestic waterfalls. Whether you're wandering through charming local markets or exploring ancient ruins, Roboré promises an unforgettable cultural adventure.

  • The peak season is from October to December
  • The off-peak season is from May to July

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz
$43 nightly
The price is $43 total per night from Sep 10 to Sep 11
$43 total
Sep 10 - Sep 11
9.4/10 Exceptional! (51 reviews)
"The"

Reviewed on Jul 28, 2025

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
$103 nightly
The price is $103 total per night from Sep 5 to Sep 6
$103 total
Sep 5 - Sep 6
9/10 Wonderful! (191 reviews)
"all"

Reviewed on Jun 5, 2025

Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$134 nightly
The price is $134 total per night from Sep 9 to Sep 10
$134 total
Sep 9 - Sep 10
8.8/10 Excellent! (322 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
See all 292 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Cruz vacation package cost?
From as low as $371. Yes, you read that correctly. Our Santa Cruz packages are a great way to make your dollars go much further. Bundle your hotels, flights and rental car and discover this popular destination.
How do I get a cheap travel package to Santa Cruz?
Browse and book everything all in one place with our Santa Cruz vacation packages. You'll find deals on hotels, flights and more that'll keep your wallet happy and your adventurous spirit alive. And, with more than 550 air carriers and 1,000,000 hotel options worldwide to select from, you have countless opportunities to mix and match.
How far in advance should I book my Santa Cruz vacation?
It can be difficult to know exactly when is the perfect time to book your trip to Santa Cruz. But typically the earlier you book, the better the prices. In some cases, you can reserve your flights and hotels up to 12 months prior to departure. If you're thinking of a last-minute getaway, no need to worry! There are plenty of fantastic deals popping up on Expedia all the time.
What does an Expedia Santa Cruz travel package include?
Flights, hotels and rental cars — we've got them covered. With Expedia, you can create your Santa Cruz package your way. All you have to do is figure out exactly what you need. Once you've made your booking, you can add extras like tours and activities. The more you bundle, the greater the savings!
What should I know before booking a Santa Cruz travel package?
Whether it's adventure or relaxation you're craving, a Santa Cruz vacation package lets you organize your escape your way. Plus, you'll score great discounts when you combine your accommodations with your flights and rental car. The more you bundle, the bigger the savings!
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You can pick and choose your flights, hotels and more. We have more than 550 airline partners worldwide, so you have lots of choice when arranging your Santa Cruz escape.
Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
If you want to spread the price of your hotel and activities over numerous payments, Expedia can help you out. Paying the total amount for your travel upfront isn't always the best way to budget for your break, so we've joined forces with online lender Affirm to give you financial flexibility. Book Now, Pay Later and reduce the stress of saving to travel.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes, it's possible to cancel your Santa Cruz booking if your plans have been upended. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel your booking free of charge if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre which includes heritage architecture and heritage elements as well as a large group of people

Plaza 24 de Septiembre

4.5/5(26 reviews)

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre
San Lorenzo Cathedral which includes heritage elements, heritage architecture and a church or cathedral

San Lorenzo Cathedral

4.5/5(15 reviews)

One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.

San Lorenzo Cathedral

Ventura Mall

4.5/5(28 reviews)

During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.

Ventura Mall
Explore a world of travel with Expedia

Explore a world of travel with Expedia

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.